H2N2V1, Main, Exploration, bibRecord, 000897

Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Identifieur interne : 000897 ( Main/Exploration ); précédent : 000896; suivant : 000898

Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Auteurs : Florens Lohrmann ; Ronald Dijkman ; Silke Stertz ; Volker Thiel ; Otto Haller ; Peter Staeheli ; Georg Kochs

Source :

Journal of Virology [ 0022-538X ] ; 2013.

RBID : PMC:3807286

Abstract

Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807286

DOI: 10.1128/JVI.01271-13
PubMed: 23926347
PubMed Central: 3807286

Affiliations:

Le document en format XML

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Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Source :

Abstract

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